Keel and her team surveyed a complete of 2,181 college girls in 1982, 1992, 2002 and 2012 about their health and weight-reduction plan habits and adopted up with the first three teams 10 years later. The exception to the rule is the DOT1 household, members of which methylate K79 in the globular region of histone H3 and which are structurally not associated to SET-domain proteins four - 6 Recent work suggests that SET-domain-containing proteins methylate a couple of proteins along with histones (see later)